tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate

tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate - Names and Identifiers

Name	H2N-PEG2-tBu
Synonyms	H2N-PEG2-tBu H2N-PEG2-CH2CH2COOtBu Amino-PEG2-t-butyl ester Amino-PEG2-acid -t-Butyl ester tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate 3-[2-(2-Aminoethoxy)ethoxy]propanoic acid 1,1-dimethylethyl ester tert-Butyl 9-AMino-4,7-dioxanonanoate (H2N-PEG2-tBu) tert-butyl 9-AMino-4,7-dioxanonanoate
CAS	756525-95-8

tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate - Physico-chemical Properties

Molecular Formula	C11H23NO4
Molar Mass	233.3
Density	1.014±0.06 g/cm3(Predicted)
Boling Point	313.7±22.0 °C(Predicted)
pKa	8.74±0.10(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Use	NH2-PEG2-C2-Boc is a PROTAC linker and belongs to the PEG class. NH2-PEG2-C2-Boc can be used to synthesize PROTAC molecules. NH2-PEG2-C2-Boc is also a non-cleavable ADC linker with 2-unit PEG, which can be used to synthesize antibody-coupled drugs (ADC).
In vitro study	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate - Upstream Downstream Industry

Downstream Products

Azido-PEG2-acid

tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate - Introduction

Target
PEGs

Alkyl/ether

Non-cleavable

In vitro study

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Last Update：2024-04-10 22:29:15

tert-Butyl 3-(2-(2-aminoethoxy)ethoxy)propanoate - Introduction

H2N-PEG2-tBu, also known as TBD analogs, is an organic compound. It has the following properties:

1. Appearance and taste: H2N-PEG2-tBu is a colorless liquid with an odor similar to esters.
2. Solubility: it is soluble in organic solvents such as alcohols, ethers and ether solution, slightly soluble in water.
3. Stability: The compound is stable at room temperature, but may decompose under high temperature and high humidity conditions.
4. Chemical properties: H2N-PEG2-tBu is a basic substance, can react with acidic compounds.

The main uses of the H2N-PEG2-tBu include:

1. As catalyst and base catalyst in chemical synthesis.
2. For the synthesis of polyurethane and polyamide and other polymer materials intermediates.
3. Used as a base catalyst in the field of organic synthesis, such as esterification and condensation reactions.

Regarding the preparation method of H2N-PEG2-tBu, a common method is to use Uspensky (U.S. Phillips) catalyst to combine ethylene glycol with 4-chloro-7-hydroxy-3, 4-Dioxa-5-nonanoic acid butyl ester is obtained by reaction.

When using and handling H2N-PEG2-tBu, please note the following safety information:

1. Wear personal protective equipment such as safety glasses and gloves to avoid direct contact with skin and eyes.
2. Avoid inhaling the vapor or dust of the substance, and use respiratory protective equipment if necessary.
3. Follow the correct operating procedures to ensure that the work area is well ventilated.
4. Avoid contact with oxidants, strong acids, strong bases and other substances to prevent dangerous reactions.
5. When splashing into eyes or skin, rinse immediately with plenty of water and seek medical assistance as soon as possible.

Last Update：2024-04-09 21:54:55